CS Genetics has developed a radically new approach to single cell, performing high-fidelity indexing of molecules across thousands of cells simultaneously in single-tube, solution-phase reactions – empowering researchers with a simple, scalable, and adaptable platform.
Current tools for single cell genomics involve complex laboratory frameworks, such as proprietary instruments, microfluidic or manual emulsions, and combinatorial indexing.
The high cost of single cell analysis remains a major barrier, limiting the number of cells, samples, and replicates researchers can afford to process.
Kinetic Confinement is a novel thermodynamic approach that controls molecular diffusion to enable high-fidelity single-cell indexing, all within standard lab plasticware such as PCR tubes and plates. The versatility of Kinetic Confinement enables simple, fast, and flexible single cell experiments, while allowing routine scaling of samples analyzed across multiple orders of magnitude.
For additional information about Kinetic Confinement and the SimpleCell platform, please see our bioRxiv pre-print.
CPair beads are novel, bifunctional cell pairing reagents that deliver index sequences directly to single cells.
SimpleCell distinguishes all major immune lineages and rare subpopulations in PBMCs—enabling deep insights from heterogeneous biological samples.
SimpleCell analysis of human PBMCs identified all major immune cell types and subtypes through clustering and marker gene expression. The UMAP plots, dot plot, and feature expression maps illustrate distinct cell populations and their characteristic gene markers across 15,650 high-quality cells.
Discover how SimpleCell 3′ Gene Express can accelerate your single cell research with seamless integration and flexible scalability.
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